The thin layered structure and porous structure in two-dimensional metal organic framework (2D MOF) nanosheet has rapidly developed as promising catalytic materials in the electrocatalytic reaction, because 2D MOF nanosheet not only provides larger active surface area, more edge active sites, and larger activation surface area, but also can achieve rapid mass transfer and accelerate the reaction process in catalytic reactions. However, despite extensive research, the practical application of 2D MOFs remains limited by challenges in scalability, stability, and integration with real-world devices. Herein, we summarized the latest progress in the deliberate engineering of 2D MOF nanosheet as catalyst for electrocatalytic reaction, with a particular focus on their electrocatalytic and energy-related applications. The two major synthetic pathways of 2D MOF nanosheet are reviewed, including top-down method and down-top method, and the recent development of synthetic method is also discussed. Unlike existing reviews that primarily focus on theoretical aspects or specific applications, this work integrates insights from both experimental and computational studies, offering a holistic view of the field. This review highlights the importance of rational material design, scalable synthesis methods, and robust performance evaluation protocols. By bridging the gap between fundamental research and practical application, this review aims to accelerate the transition of 2D MOFs from laboratory-scale studies to real-world solutions, ultimately contributing to the development of sustainable and efficient energy systems.