Structure-based design of an aromatic helical foldamer-protein interface

Chem. Sci., 2025, Accepted Manuscript
DOI: 10.1039/D5SC01826A, Edge Article

Open Access

&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Lingfei Wang, Céline Douat, Johannes Sigl, Sai Reddy Post, Lucile Fischer, Béatrice Langlois d’Estaintot, Zhiwei Liu, Vojislava Pophristic, Yuwei Yang, Yingkai Zhang, Ivan Huc
The starting point of this study is the solid state structure of a complex between human carbonic anhydrase II (HCAII) and a helically folded tetradecaamide aromatic foldamer with a nanomolar…
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