Chem. Sci., 2025, Accepted Manuscript
DOI: 10.1039/D4SC06391K, Edge Article
Open Access Open Access
Tyler D. Casselman, Mithun Madhusudhanan, Binh Khanh Mai, Peng Liu, Brian M. Stoltz
A potassium tert-butoxide (KOt-Bu)-mediated Mannich reaction between α-substituted-γ-lactams and N-silyl imines is reported. N-silyl imines are generated in situ from readily available aryl nitriles and directly combined with the lactams,…
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