Diastereoselective Arylation of Bis-Lactim Ethers Catalyzed by N-coordinating Ylide-Functionalized Phosphine (NYPhos)

Chem. Sci., 2025, Accepted Manuscript
DOI: 10.1039/D5SC02814K, Edge Article

Open Access

&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Daniel Sowa Prendes, Julian Löffler, Ivan Martins Barreto, Nagesh Sankaran, Henning Remm, Ronaldo Oliveira, Viktoria H. Gessner, Lukas J. Goossen
The palladium-catalyzed diastereoselective arylation of Schöllkopf bis-lactim ethers has recently emerged as a convenient entry to enantioenriched arylglycine derivatives. Key limitations of the prototypical protocol have now been overcome by…
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