Chiral iron oxides and hydroxides have garnered considerable interest owing to the unique combination of chirality and magnetism. However, it remains elusive how to improve their g-factor, which is critical…
Electrochemically driven carbon–carbon formation is receiving considerable interest in organic synthesis. In this study, we present an electrochemically driven method for the formation of C(sp3)–C(sp3) bonds using readily available allylic…
Navtemadlin is a potent inhibitor of the p53-MDM2 protein-protein interaction, which plays a critical role in the proliferation of p53-wildtype tumours. Whilst Navtemadlin has progressed to multiple Phase III clinical…
The combination of multinuclear NMR spectroscopy with both 17O isotopic enrichment and DFT calculations provided detailed insight into both the bulk and surface structure of γ-Al2O3.Comparison of experimental 17O NMR…
The complex pathology of Alzheimer’s disease includes various pathogenic components, such as metal-free amyloid-β (Aβ) and metal-bound Aβ (metal–Aβ). Here we report an effective strategy for developing novel heterocycle-fused 1,4-benzoquinone…
Cyclic boronates are versatile synthons for organic synthesis and for introducing ring systems into bioactive molecules. Existing synthetic methods have narrow substrate scope and the synthesis of α-substituted cyclic boronates…
U.S. ENERGY INFORMATION ADMINISTRATION WASHINGTON DC 20585 FOR IMMEDIATE RELEASE March 11, 2025 The U.S. Energy Information Administration (EIA) revised its forecast for 2025 average U.S. benchmark Henry Hub natural…
The world’s transition from a fossil-fuel-driven society to a future net-zero or negative carbon dioxide emission society will require a significant scale-up of Power-to-X technologies to capture and convert CO2…
In this study, we present the first reported use of bioorthogonal click chemistry with rhenium-188 for radiolabelling of an anti-c-Met VHH Nanobody®. We employed a “chelate-then-click” strategy, wherein a bifunctional…
The native and tunable microscale fluid manipulation accessible within 3D-printed configurations can be a transformative tool in biosensing, promoting mass transport and sample mixing to boost assay performance. In this…
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