Understanding the chemical reactions that led to the origin of life is a fundamental challenge. The formose reaction, an abiotic pathway to monosaccharides, provides a mechanism of sugar formation from…
The integration of two entirely unrelated organic reactions into a novel reaction poses a formidable challenge. While diatomic catalysts (DACs) have exhibited promise as a framework for realizing this concept,…
Fluorescent off-on probes based on a modular design where an analyte sensitive PET moiety is attached to a fluorophore are extremely successful. Here we report a new modular fluorescence probe…
Computational (DFT and DLPNO-CCSD(T)) calculations along with experimental tools (deuterium labelling, kinetic studies using VTNA, ESI-HRMS and UV) are used to probe the mechanism of a Pd(II)-catalyzed enantioselective carbene insertion…
Although enantioselective hydrofunctionalizations of nitrones are established for synthesis of various types of chiral hydroxylamines, the asymmetric catalytic hydrophosphinylation of nitrones remains highly challenging. Herein, an efficient asymmetric hydrophosphinylation of…
In-brief analysis March 18, 2025 Data source: U.S. Energy Information Administration, Hourly Electric Grid MonitorNote: ERCOT=Electric Reliability Council of Texas; CT=central time …
β-Galactoside prodrugs, activated by β-galactosidase (β-gal) highly expressed in some cancer cells, have been explored as anticancer agents for three decades. However, the distribution of β-gal lacks sufficient specificity to…
Previously we posited that a systematic and general description of stereoisomerism could be based upon the principles of the polytopal rearrangement model. The most daunting challenge to this end is…
Multiple resonance-induced thermally activated delayed fluorescence (MR-TADF) materials with pure-red gamut are demanded for high-definition organic light-emitting diodes (OLEDs) displays. To achieve efficient pure-red OLEDs with excellent color purity, we…
Misregulation of transmembrane ion transport in biological systems has been linked to a variety of diseases. As a result, supramolecular chemists have been trying to develop small molecules that facilitate…
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