Proton transfer during reduction of the catalytic metallo-cofactors of the three nitrogenase isozymes
Nitrogenase catalyzes biological nitrogen fixation, the conversion of atmospheric N2 into bioavailable ammonia. The three nitrogenase isozymes—Mo-nitrogenase, V-nitrogenase, and Fe-nitrogenase—utilize catalytic cofactors distinguished by their metal composition (Fe7M, M =…