Molecular discovery within the vast chemical space remains a significant challenge due to the immense number of possible molecules and limited scalability of conventional screening methods. To approach chemical space…
In-brief analysis July 30, 2025 Data source: Standard International Trade Classification data published by the U.S. Census BureauNote: Prices are adjusted for inflation. …
Immunotherapy targeting immune checkpoints has emerged as a promising strategy in cancer treatment; however, the heterogeneous and dynamic tumor microenvironment (TME) imposes critical constraints on therapeutic outcomes. Tryptophan 2,3-dioxygenase (TDO),…
Commercialising supramolecular chemistry has proved challenging, but encouraging stories are beginning to emerge. In this editorial we present accounts of programs aimed at diabetes management, humidity sensing, antimicrobials, shock absorbing…
Post-synthetic metalation and metathesis chemistry are central to rational synthesis of metal-organic frameworks (MOFs) that are unavailable by direct self-assembly. The inherent microcrystallinity and heterogeneous nature of many MOFs renders…
Developing non-precious metal electrocatalysts with high activity and high chlorine (Cl–) corrosion resistance under industrial-scale current density remains challenging for large-scale seawater splitting. Targeting at this problem, we rationally design…
Solid-state lithium metal batteries represent a critical frontier in energy storage technology, yet persistent interfacial instability between Li metal anode and solid electrolytes generates detrimental electrochemical-mechanical interactions that undermine cycling…
Nanoscale dimerization geometries dictate transmembrane receptor phosphorylation dynamics, yet current methods fail to directly correlate spatial receptor organization with real-time phosphorylation states in situ. Receptor tyrosine kinase (RTK) activation, essential…
In-depth analysis July 29, 2025 In our Annual Energy Outlook 2025 (AEO2025), we project regional differences in natural gas markets will encourage increased natural gas…
Chem. Sci., 2025, Advance ArticleDOI: 10.1039/D5SC03828F, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Yasunari Tamai, Midori Akiyama, Lorenzo Vallan, Daiki…
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