A unique three-enzyme cascade mediates efficient regioselective and stereospecific epoxytetrahydrofuran ring formation in the deoxyverrucosidin biosynthesis
The fungal octaketide deoxyverrucosidin shares the same α-pyrone core with several nonaketides, including aurovertin, citreoviridin, and asteltoxin. Deoxyverrucosidin is featured by its unique epoxytetrahydrofuran ring. In this study, we demonstrate…