A sequential esterification-ring closing metathesis-Nozaki–Hiyama–Kishi strategy for constructing a natural product-like library of tetrahydrofuran-containing macrolides

Chem. Sci., 2025, Advance Article
DOI: 10.1039/D5SC00591D, Edge Article

Open Access

&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Daniel Driedger, Darryl M. Wilson, Robert Britton
Using the TSNaP strategy, a virtual library of THF-containing macrolides was designed. Here, the synthesis of a large subsection of this library comprising 170 targeted compounds is described along with the synthetic challenges encountered.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry