A practical photocatalytic strategy for radical (deuterio)difluoromethylation from imidazolium reagents

Chem. Sci., 2025, Accepted Manuscript
DOI: 10.1039/D5SC02691A, Edge Article

Open Access

&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Chao Sun, Yinpu Shen, Heyin Li, Zhen Wang, Yifan Li, Mengjun Huang, Zhenlei Zou, Jing Liu, Ao Liu, Yi Pan, Weigang Zhang, Yi Wang
The difluoromethyl group (CF₂H) has garnered significant interest in medicinal chemistry owing to its unique biochemical and physicochemical properties. Its deuterated counterpart (CF₂D), building on the established utility of CF₂H,…
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