A Leigh syndrome mutation perturbs long-range energy coupling in respiratory complex I

Chem. Sci., 2025, Accepted Manuscript
DOI: 10.1039/D4SC04036H, Edge Article

Open Access

&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Franziska Hoeser, Patricia Saura, Caroline Harter, Ville Kaila, Thorsten Friedrich
Respiratory complex I is a central enzyme of cellular energy metabolism that couples electron transfer with proton translocation across a biological membrane. In doing so, it powers oxidative phosphorylation that…
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