Observation of Solvent Enantio-Isotope Effect in Asymmetric Ring-Opening of Cyclic Diaryliodoniums with Selenocyanate


Chem. Sci., 2025, Accepted Manuscript
DOI: 10.1039/D5SC00014A, Edge Article
Open Access Open Access
Yuanyuan Li, Chenyu Tao, Longhui Duan, Zhenhua Gu
A Cu-catalyzed asymmetric coupling reaction between cyclic diaryliodoniums and the ambident nucleophile KSeCN was reported. Utilizing water as a co-solvent (CH2Cl2/H2O) achieves high chemoselectivity by forming a nitrogen-hydrogen-bond, thereby blocking…
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