Structural basis of the residence time of adenosine A2A receptor ligands revealed by NMR

Chem. Sci., 2025, Accepted Manuscript
DOI: 10.1039/D5SC02398J, Edge Article

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&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Takumi Ueda, Tomoki Tsuchida, Masanori Kurita, Takuya Mizumura, Shunsuke Imai, Yutaro Shiraishi, Yutaka Kofuku, Shukei Miyagawa, Kaori Fukuzawa, Koh Takeuchi, Ichio Shimada
Residence time, which refers to the average duration a drug remains bound to its receptor, is a crucial parameter in determining its pharmacological effects. However, the mechanisms governing the residence…
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