Cooperativity in the assembly of H-bonded duplexes of synthetic recognition-encoded melamine oligomers

Chem. Sci., 2025, Advance Article
DOI: 10.1039/D4SC08591D, Edge Article

Open Access

&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Mohit Dhiman, Luis Escobar, Joseph T. Smith, Christopher A. Hunter
Fluorescence experiments (FRET) show that synthetic sequence-complementary polymers (REMO) form H-bonded duplexes in a highly cooperative all-or-nothing process that mirrors the behaviour of the DNA double helix.
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