Pyridine-N-oxide Catalyzed Asymmetric N-Acylative Desymmetrization of Sulfonimidamides

Chem. Sci., 2025, Accepted Manuscript
DOI: 10.1039/D5SC01270H, Edge Article

Open Access

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Cui-Mei Guo, Fang-Yuan Zhang, Yin Tian, Ming-Sheng Xie, Hai-Ming Guo
A highly efficient enantioselective N-acylative desymmetrization of sulfonimidamides with chloroformates was reported using chiral 4-arylpyridine-N-oxide as the catalyst, affording N-acylative sulfonimidamides with sulfur(VI)-stereocenters in high yields and excellent enantioselectivities. Experiments…
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