May 2025

X-ray fluorescence microscopy and X-ray absorption spectroscopy reveal the stability of the plecstatin-1 scaffold in biological model systems: comparison of Ru, Os and Ir analogues

Plecstatin-1 (Cl; p-cym = p-cymene, pca = (4-fluorophenyl-2-pyridinecarbothioamide)) is an organometallic anticancer compound of the ruthenium “piano-stool”/“half-sandwich” class which displays promising pre-clinical results. Its mode of action is ascribed to…